Novamentine 375 mg is a fixed-dose combination of Amoxicillin Trihydrate (equivalent to 250 mg amoxicillin base) and Potassium Clavulanate (equivalent to 125 mg clavulanic acid) per tablet. Manufactured by Micro Labs Ltd and approved by NAFDAC, this formulation provides potent antibacterial action by combining the cell-wall targeting of amoxicillin with natural beta-lactamase inhibition via clavulanic acid—expanding its effectiveness across resistant strains.
Key Applications:
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Treatment of bacterial infections such as acute sinusitis, urinary tract infections, skin and soft tissue infections, dental abscesses, and cellulitis.
Dosage Guidance:
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Adults and children ≥40 kg: One tablet three times a day, preferably with food to minimize gastrointestinal discomfort.
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Renal Impairment: Dosage should be adjusted downward based on kidney function.
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Duration: Typically up to 14 days—longer use only following professional medical review.
Important Safety Notes:
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Contraindications: Hypersensitivity to penicillins or cephalosporins; history of amoxicillin/clavulanate-induced jaundice or liver dysfunction.
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Warnings: Risk of serious allergic reactions (e.g., anaphylaxis); hepatic events (rare, mostly reversible); antibiotic-associated colitis; potential for crystalluria or lab test interference.
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Drug Interactions: May amplify effects of anticoagulants (e.g., warfarin). Monitor labs if co-administered.
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Side Effects: Common: diarrhea, nausea, vomiting. Less common: rash, elevated liver enzymes, dizziness.
Storage: Store below 30 °C, in a dry place, away from direct sunlight. Keep out of reach of children.
Administration Reminder: This is a prescription-only medication. Complete the full course even if symptoms improve—never self-prescribe.
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